一、基本信息
李墅，理学（生物化学与分子生物学）博士，石河子大学药学院药学系副教授。主要致力于基于多肽的抗耐药菌新药发现、设计合成以及作用机制的研究，在chemical communications, acs infectious diseases, bioconjugate chemistry等学术期刊发表论文8篇。
二、讲授课程
本科生课程：分析化学、工业药物分析
研究生课程：生物技术制药
三、代表性成果（从近到远……）
1. 代表论文
[1] li s, wang z, song s, tang y, zhou j, liu x, zhang x, chang m, wang k, peng y, membrane-active all-hydrocarbon-stapled α-helical amphiphilic tat peptides: broad-spectrum antibacterial activity and low incidence of drug resistance. acs infectious diseases, 2024.04.12, accept, doi:10.1021/acsinfecdi s.4c00173.
[2] li s, song s, liu x, zhang x, liang x, chang x, zhou d, han j, nie y, guo c, yao x, chang m, peng y, development of a decafluorobiphenyl cyclized peptide targeting the nemo–ikkα/β interaction that enhances cell penetration and attenuates lipopolysaccharide-induced acute lung injury, bioconjugate chemistry, 2024.4.16, accept, doi: 10.1021/acs.bioconjchem.4c00122.
[3] li s, guo c, zhang x, liu x, mu j, liu c, et al. self-assembling modified neuropeptide s enhances nose-to-brain penetration and exerts a prolonged anxiolytic-like effect. biomater. sci, 2021. doi: 10.1039/d1bm00380a.
[4] li s, zhang x, guo c, peng y, liu x, wang b, et al. hydrocarbon staple constructing highly efficient α-helix cell-penetrating peptides for intracellular cargo delivery. chem. commun, 2020; 56(100):15655-15658.
[5] jiang j, wang z, liang, x. y.; nie, y. y.; chang, x.; xue, h. x.; li, s.; min, c. intranasal mmi-0100 attenuates a beta (1-42)- and lps-induced neuroinflammation and memory impairments via the mk2 signaling pathway. front. immunol, 2019, 10, 16.
[6] jiang, j. h.; peng, y. l.; liang, x. y.; li, s.; chang, x.; li, l. f.; chang, m. centrally administered cortistation-14 induces antidepressant-like effects in mice via mediating ghrelin and gaba(a) receptor signaling pathway. front. pharmacol. 2018, 9, 12.
[7] jiang, j. h.; jin, w. d.; peng, y. l.; liang, x. y.; li, s.; wei, l. j.; lei, z. p.; li, l. f.; chang, m. the role of cortistatin-14 in the gastrointestinal motility in mice. pharmacol. rep. 2018, 70, 355-363.
[8] jiang, j. h.; jin, w. d.; peng, y. l.; he, z.; wei, l. j.; li, s.; wang, x. l.; chang, m.; wang, r. in vivo and vitro characterization of the effects of kisspeptin-13, endogenous ligands for gpr54, on mouse gastrointestinal motility, eur. j. pharmacol. 2017, 794, 216-223.
2. 发明专利
[1] 彭雅丽，李墅，常民，宋世博；“烯烃装订的两亲性肽及其制备方法和应用”，申请号：2023102895231 申请日：2023-01-28.
[2] 彭雅丽，李墅，张兴姣，高飞云，常民；“十氟联苯环化修饰的 nbd 多肽类似物及其制备方法和应用”，申请号：202110619708 申请日：2021-08-06.已授权
[3] 常民, 穆静, 彭雅丽, 李墅, 王沛, 刘春霞, 姜锦红; “脂肪酸修饰神经肽 s 类似物及其合成与应用”, 申请号：201810408033.8 申请日：2018-05-02. 已授权.
[4] 常民, 彭雅丽, 李墅, 薛宏祥; “一种高效的前列腺特异性膜抗原配体 psma-617 的固相制备方法”, 申请号：201810984865.4 申请日：2018-08-28.已授权.
四、800cc全讯白菜的联系方式
1. e-mail：lishu14@lzu.edu.cn
2. 通讯地址：新疆维吾尔自治区石河子市，北2路59号，石河子大学医学校区，药学院
3. 邮编：832002